New glycopolymers as multivalent systems for lectin recognition

Abstract

New types of glycopolymers have been designed and evaluated as multivalent systems for lectin recognition. They were prepared by living Anionic Ring-Opening Polymerization (AROP) of disubstituted cyclopropane-1,1-dicarboxylates and thiol–ene post-modification. Fully modified oligomers with single or geminal sugar substituents located on every third carbon alongside the macromolecular scaffold were obtained under mild conditions. The resulting glycopolymers have shown efficient binding potency towards concanavalin A.