Issue 103, 2014

d-Glucose based bisacrylamide crosslinker: synthesis and study of homogeneous biocompatible glycopolymeric hydrogels

Abstract

The ability of sugar pendants in glycopolymers to mimic that on the cell surface can be used as a reliable method for the site specific delivery of drugs. In the search for new possibilities, we herein report a D-glucose based synthesis of hitherto unknown bisacrylamide crosslinker (Glc-bis), a related acrylamide monomer (Glc-acryl), with hemiacetal functionality. A one pot process to transform the synthesized Glc-acrylamides to sterilized homogeneous glycopolymeric gel (Glc-gel) was investigated using radiation induced polymerization technique. The Glc-gel was subjected to swelling studies, viscoelastic, and thermal analysis. The in vitro cytotoxicity test revealed that the constituents (Glc-acryl and Glc-bis) as well as the Glc-gel were non toxic to the cells and the cells grew normally in their presence. The synthesized Glc-gel was found to show good affinity to lectin Con A demonstrating that replacing hydroxyl group in D-glucose moiety with amide bond does not largely affect its interaction with lectins.

Graphical abstract: d-Glucose based bisacrylamide crosslinker: synthesis and study of homogeneous biocompatible glycopolymeric hydrogels

Supplementary files

Article information

Article type
Paper
Submitted
29 Aug 2014
Accepted
31 Oct 2014
First published
03 Nov 2014

RSC Adv., 2014,4, 59370-59378

Author version available

D-Glucose based bisacrylamide crosslinker: synthesis and study of homogeneous biocompatible glycopolymeric hydrogels

J. K. Ajish, K. S. Ajish Kumar, M. Subramanian and M. Kumar, RSC Adv., 2014, 4, 59370 DOI: 10.1039/C4RA09481F

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