Issue 101, 2014

A new approach for fused isoindolines via hexadehydro-Diels–Alder reaction (HDDA) by Fe(0) catalysis

Abstract

A simple method has been developed for the synthesis of fused isoindolines via a cascade HDDA approach catalyzed by Fe2(CO)9. In this work, a 1,3-diyne was involved in a [4 + 2] cycloisomerization with a diynophile to give an aryne intermediate, which was subsequently trapped with –OH nucleophile to beget the fused isoindolines in high yields.

Graphical abstract: A new approach for fused isoindolines via hexadehydro-Diels–Alder reaction (HDDA) by Fe(0) catalysis

Supplementary files

Article information

Article type
Paper
Submitted
04 Sep 2014
Accepted
20 Oct 2014
First published
27 Oct 2014

RSC Adv., 2014,4, 57547-57552

Author version available

A new approach for fused isoindolines via hexadehydro-Diels–Alder reaction (HDDA) by Fe(0) catalysis

J. K. Vandavasi, W. Hu, C. Hsiao, G. C. Senadi and J. Wang, RSC Adv., 2014, 4, 57547 DOI: 10.1039/C4RA12376J

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