Issue 5, 2015
From the journal:

Soft Matter

The effect of solvent choice on the gelation and final hydrogel properties of Fmoc–diphenylalanine†

Jaclyn Raeburn,a   Cristina Mendoza-Cuenca,b   Beatrice N. Cattoz,c   Marc A. Little,a   Ann E. Terry,d   Andre Zamith Cardoso, ORCID logo a   Peter C. Griffithsc  and  Dave J. Adams*a  

* Corresponding authors

a Department of Chemistry, University of Liverpool, Crown Street, Liverpool, UK
E-mail: d.j.adams@liverpool.ac.uk

b Department of Chemical Engineering, Faculty of Sciences, 18071 Granada, Spain

c School of Life Sciences, University of Sussex, Chichester II Building, Falmer, UK

d Rutherford Appleton Laboratory, Science and Technology Facilities Council, Didcot, Oxfordshire OX11 0QX, UK

Abstract

Gels can be formed by dissolving Fmoc–diphenylalanine (Fmoc–PhePhe or FmocFF) in an organic solvent and adding water. We show here that the choice and amount of organic solvent allows the rheological properties of the gel to be tuned. The differences in properties arise from the microstructure of the fibre network formed. The organic solvent can then be removed post-gelation, without significant changes in the rheological properties. Gels formed using acetone are meta-stable and crystals of FmocFF suitable for X-ray diffraction can be collected from this gel.

Graphical abstract: The effect of solvent choice on the gelation and final hydrogel properties of Fmoc–diphenylalanine

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Article information

DOI
https://doi.org/10.1039/C4SM02256D
Article type
Paper
Submitted
13 Oct 2014
Accepted
08 Dec 2014
First published
08 Dec 2014
This article is Open Access
Creative Commons BY license

Soft Matter, 2015,11, 927-935

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The effect of solvent choice on the gelation and final hydrogel properties of Fmoc–diphenylalanine

J. Raeburn, C. Mendoza-Cuenca, B. N. Cattoz, M. A. Little, A. E. Terry, A. Zamith Cardoso, P. C. Griffiths and D. J. Adams, Soft Matter, 2015, 11, 927 DOI: 10.1039/C4SM02256D

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