Silicon nanowire-based therapeutic agents for in vivo tumor near-infrared photothermal ablation

Yuanyuan Su; Fei Peng; Xiaoyuan Ji; Yimei Lu; Xinpan Wei; Binbin Chu; Chongxi Song; Yanfeng Zhou; Xiangxu Jiang; Yiling Zhong; Shuit-Tong Lee; Yao He

doi:10.1039/C4TB00100A

Silicon nanowire-based therapeutic agents for in vivo tumor near-infrared photothermal ablation†

Yuanyuan Su,‡^a Fei Peng,‡^a Xiaoyuan Ji,^a Yimei Lu,^a Xinpan Wei,^a Binbin Chu,^a Chongxi Song,^a Yanfeng Zhou,^a Xiangxu Jiang,^a Yiling Zhong,^a Shuit-Tong Lee*^a and Yao He*^a

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* Corresponding authors

^a Institute of Functional Nano & Soft Materials (FUNSOM) and Collaborative Innovation Center of Suzhou Nano Science and Technology, Soochow University, Suzhou 215123, China
E-mail: apannale@suda.edu.cn, yaohe@suda.edu.cn
Fax: +86 512 6588 2846
Tel: +86 512 6588 0946

Abstract

The first example of silicon nanowire (SiNW)-based in vivo tumor phototherapy is presented. Gold nanoparticle (AuNP)-decorated SiNWs are employed as high-performance NIR hyperthermia agents for highly efficacious in vivo tumour ablation. Significantly, the overall survival time of SiNW-treated mice is drastically prolonged, with 100% of mice being alive and tumor-free for over 8 months, which is the longest survival time ever reported for tumor-bearing mice treated with nanomaterial-based NIR hyperthermia agents.

Journal of Materials Chemistry B

Silicon nanowire-based therapeutic agents for in vivo tumor near-infrared photothermal ablation†

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Silicon nanowire-based therapeutic agents for in vivo tumor near-infrared photothermal ablation

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