Issue 24, 2014

Solid phase synthesis of functionalised SAM-forming alkanethiol–oligoethyleneglycols

Abstract

We present an efficient solid phase synthesis methodology that provides easy access to a range of functionalised long-chain alkanethiol–oligoethyleneglycols that form well-defined self-assembled monolayers on gold and are compatible with pre- or post-assembly conjugation of (bio)molecules. We demonstrate the versatility of our synthetic route by synthesising LCAT–OEGs with a range of functional moieties, including peptides, electro-active redox groups, chemical handles for post-assembly conjugation of (bio)molecules, and demonstrate the application of our LCAT–OEG monolayers in immunosensing, where they show good biocompatibility with minimal biofouling.

Graphical abstract: Solid phase synthesis of functionalised SAM-forming alkanethiol–oligoethyleneglycols

Supplementary files

Article information

Article type
Communication
Submitted
10 Apr 2014
Accepted
22 Apr 2014
First published
23 Apr 2014
This article is Open Access
Creative Commons BY license

J. Mater. Chem. B, 2014,2, 3741-3744

Author version available

Solid phase synthesis of functionalised SAM-forming alkanethiol–oligoethyleneglycols

J. Murray, D. Nowak, L. Pukenas, R. Azhar, M. Guillorit, C. Wälti, K. Critchley, S. Johnson and R. S. Bon, J. Mater. Chem. B, 2014, 2, 3741 DOI: 10.1039/C4TB00573B

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