Issue 7, 2015

Self-assembled micelles of amphiphilic PEGylated rapamycin for loading paclitaxel and resisting multidrug resistant cancer cells

Abstract

Self-assembled micelles of amphiphilic PEG–rapamycin conjugates loaded with paclitaxel have been developed for co-delivery and simultaneous intracellular release of paclitaxel and rapamycin, bypassing the cancer cell drug resistant mechanism and maximising the synergy of dual-drug combinational therapy. This novel nanomedicine offers 20-fold improved potency over free paclitaxel against a model multidrug resistant human breast cancer cell.

Graphical abstract: Self-assembled micelles of amphiphilic PEGylated rapamycin for loading paclitaxel and resisting multidrug resistant cancer cells

Supplementary files

Article information

Article type
Communication
Submitted
01 Oct 2014
Accepted
19 Jan 2015
First published
26 Jan 2015
This article is Open Access
Creative Commons BY license

J. Mater. Chem. B, 2015,3, 1204-1207

Author version available

Self-assembled micelles of amphiphilic PEGylated rapamycin for loading paclitaxel and resisting multidrug resistant cancer cells

W. Tian, J. Liu, Y. Guo, Y. Shen, D. Zhou and S. Guo, J. Mater. Chem. B, 2015, 3, 1204 DOI: 10.1039/C4TB01633E

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