Issue 7, 2015

Trigger responsive polymeric nanocarriers for cancer therapy

Abstract

Conventional chemotherapy for the treatment of cancer has limited specificity when administered systemically and is often associated with toxicity issues. Enhanced accumulation of polymeric nanocarriers at a tumor site may be achieved by passive and active targeting. Incorporation of trigger responsiveness into these polymeric nanocarriers improves the anticancer efficacy of such systems by modulating the release of the drug according to the tumor environment. Triggers used for tumor targeting include internal triggers such as pH, redox and enzymes and external triggers such as temperature, magnetic field, ultrasound and light. While internal triggers are specific cues of the tumor microenvironment, external triggers are those which are applied externally to control the release. This review highlights the various strategies employed for the preparation of such trigger responsive polymeric nanocarriers for cancer therapy and provides an overview of the state of the art in this field.

Graphical abstract: Trigger responsive polymeric nanocarriers for cancer therapy

Article information

Article type
Review Article
Submitted
04 Jan 2015
Accepted
09 Feb 2015
First published
27 Feb 2015

Biomater. Sci., 2015,3, 955-987

Author version available

Trigger responsive polymeric nanocarriers for cancer therapy

S. Kaur, C. Prasad, B. Balakrishnan and R. Banerjee, Biomater. Sci., 2015, 3, 955 DOI: 10.1039/C5BM00002E

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