Issue 5, 2016
From the journal:

Organic & Biomolecular Chemistry

Synthesis and activity of a novel inhibitor of nonsense-mediated mRNA decay†

Victoria J. B. Gotham,ab   Melanie C. Hobbs,a   Ryan Burgin,a   David Turton,b   Carl Smythe*b  and  Iain Coldham*a  

* Corresponding authors

a Department of Chemistry, University of Sheffield, Sheffield, UK
E-mail: i.coldham@sheffield.ac.uk

b Department of Biomedical Science, University of Sheffield, Sheffield, UK

Abstract

During efforts to prepare the known compound NMDI1, a new tetracyclic compound, called VG1, was prepared in six steps. This compound was found to have good activity as an inhibitor of nonsense-mediated mRNA decay.

Graphical abstract: Synthesis and activity of a novel inhibitor of nonsense-mediated mRNA decay

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Article information

DOI
https://doi.org/10.1039/C5OB02482J
Article type
Communication
Submitted
04 Dec 2015
Accepted
24 Dec 2015
First published
24 Dec 2015
This article is Open Access
Creative Commons BY license

Org. Biomol. Chem., 2016,14, 1559-1563

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Synthesis and activity of a novel inhibitor of nonsense-mediated mRNA decay

V. J. B. Gotham, M. C. Hobbs, R. Burgin, D. Turton, C. Smythe and I. Coldham, Org. Biomol. Chem., 2016, 14, 1559 DOI: 10.1039/C5OB02482J

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