Issue 13, 2016

Core functionalization of semi-crystalline polymeric cylindrical nanoparticles using photo-initiated thiol–ene radical reactions

Abstract

Sequential ring-opening and reversible addition–fragmentation chain transfer (RAFT) polymerization was used to form a triblock copolymer of tetrahydropyran acrylate (THPA), 5-methyl-5-allyloxycarbonyl-1,3-dioxan-2-one (MAC) and L-lactide. Concurrent deprotection of the THPA block and crystallization-driven self-assembly (CDSA) was undertaken and allowed for the formation of cylindrical micelles bearing allyl handles in a short outer core segment. These handles were further functionalized by different thiols using photo-initiated thiol–ene radical reactions to demonstrate that the incorporation of an amorphous PMAC block within the core does not disrupt CDSA and can be used to load the cylindrical nanoparticles with cargo.

Graphical abstract: Core functionalization of semi-crystalline polymeric cylindrical nanoparticles using photo-initiated thiol–ene radical reactions

Supplementary files

Article information

Article type
Paper
Submitted
10 Dec 2015
Accepted
12 Feb 2016
First published
25 Feb 2016
This article is Open Access
Creative Commons BY license

Polym. Chem., 2016,7, 2337-2341

Author version available

Core functionalization of semi-crystalline polymeric cylindrical nanoparticles using photo-initiated thiol–ene radical reactions

L. Sun, A. Pitto-Barry, A. W. Thomas, M. Inam, K. Doncom, A. P. Dove and R. K. O'Reilly, Polym. Chem., 2016, 7, 2337 DOI: 10.1039/C5PY01970B

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