Issue 46, 2015

Zinc-imidazolate polymers (ZIPs) as a potential carrier to brain capillary endothelial cells

Abstract

Herein, we report the synthesis and characterization of nanospheres of a biodegradable zinc-imidazolate polymers (ZIPs) as a proof-of-concept delivery vehicle into human brain endothelial cells, the main component of the blood-brain barrier (BBB). The ZIP particles can readily encapsulate functional molecules such as fluorophores and inorganic nanoparticles at the point of synthesis producing stable colloidal dispersions. Our results show that these biodegradable particles are not cytotoxic, and are able to penetrate and release cargo species to human brain capillary endothelial cells in vitro thus exhibiting significant potential as a novel platform for brain targeting treatments.

Graphical abstract: Zinc-imidazolate polymers (ZIPs) as a potential carrier to brain capillary endothelial cells

Supplementary files

Article information

Article type
Paper
Submitted
02 Sep 2015
Accepted
23 Oct 2015
First published
26 Oct 2015
This article is Open Access
Creative Commons BY-NC license

J. Mater. Chem. B, 2015,3, 9053-9059

Author version available

Zinc-imidazolate polymers (ZIPs) as a potential carrier to brain capillary endothelial cells

M. Chiacchia, C. Cerutti, R. Gromnicova, K. Rietdorf, I. A. Romero and D. Bradshaw, J. Mater. Chem. B, 2015, 3, 9053 DOI: 10.1039/C5TB01814E

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