Issue 39, 2016

Catalytic transformation of esters of 1,2-azido alcohols into α-amido ketones

Abstract

The esters of 1,2-azido alcohols were transformed into α-amido ketones without external oxidants through the Ru-catalyzed formation of N–H imines with the liberation of N2 followed by intramolecular migration of the acyl moiety. A wide range of α-amido ketones were obtained, and one-pot transformation into the corresponding oxazoles (or a thiazole) was demonstrated.

Graphical abstract: Catalytic transformation of esters of 1,2-azido alcohols into α-amido ketones

Supplementary files

Article information

Article type
Communication
Submitted
08 Mar 2016
Accepted
12 Apr 2016
First published
13 Apr 2016

Chem. Commun., 2016,52, 6549-6552

Catalytic transformation of esters of 1,2-azido alcohols into α-amido ketones

Y. Kim, H. K. Pak, Y. H. Rhee and J. Park, Chem. Commun., 2016, 52, 6549 DOI: 10.1039/C6CC02063A

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