Issue 2, 2017
From the journal:

Organic & Biomolecular Chemistry

Diastereoselective synthesis of trifluoromethylated 1,3-dioxanes by intramolecular oxa-Michael reaction†

Liliana Becerra-Figueroa,a   Elodie Brun,b   Michael Mathieson,b   Louis J. Farrugia,b   Claire Wilson,b   Joëlle Prunet*b  and  Diego Gamba-Sánchez ORCID logo *a  

* Corresponding authors

a Laboratory of Organic Synthesis, Bio and Organocatalysis, Chemistry Department, Universidad de los Andes, Cra 1 No. 18A-12 Q:305, Bogotá 111711, Colombia
E-mail: joelle.prunet@glasgow.ac.uk, da.gamba1361@uniandes.edu.co

b WestCHEM, School of Chemistry, University of Glasgow, Joseph Black Building, University Avenue, Glasgow G12 8QQ, UK

Abstract

A highly diastereoselective synthesis of trifluoromethylated 1,3-dioxanes is described. The reaction proceeds by an addition/oxa-Michael sequence and works efficiently under mild reaction conditions, with a good substrate scope and acceptable to good yields.

Graphical abstract: Diastereoselective synthesis of trifluoromethylated 1,3-dioxanes by intramolecular oxa-Michael reaction

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Article information

DOI
https://doi.org/10.1039/C6OB02333A
Article type
Communication
Submitted
26 Oct 2016
Accepted
23 Nov 2016
First published
23 Nov 2016
This article is Open Access
Creative Commons BY license

Org. Biomol. Chem., 2017,15, 301-305

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Diastereoselective synthesis of trifluoromethylated 1,3-dioxanes by intramolecular oxa-Michael reaction

L. Becerra-Figueroa, E. Brun, M. Mathieson, L. J. Farrugia, C. Wilson, J. Prunet and D. Gamba-Sánchez, Org. Biomol. Chem., 2017, 15, 301 DOI: 10.1039/C6OB02333A

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