Issue 11, 2016

Stereo- and regio-selective synthesis of 3′-C-substituted-(N)-methanocarba adenosines as potential anticancer agents

Abstract

Stereo- and regio-selective synthesis of 3′-C-substituted-(N)-methanocarba adenosines 3a–c as potential anticancer agents was achieved by employing stereoselective cyclopropanation, stereoselective nucleophilic addition, regioselective isopropylidene cleavage and regioselective base condensation of cyclic sulfate as key steps.

Graphical abstract: Stereo- and regio-selective synthesis of 3′-C-substituted-(N)-methanocarba adenosines as potential anticancer agents

Supplementary files

Article information

Article type
Research Article
Submitted
14 Jul 2016
Accepted
03 Sep 2016
First published
05 Sep 2016

Org. Chem. Front., 2016,3, 1472-1480

Stereo- and regio-selective synthesis of 3′-C-substituted-(N)-methanocarba adenosines as potential anticancer agents

S. D. Naik, G. Chandra, P. K. Sahu, H. Kim, S. Qu, J. Yoon and L. S. Jeong, Org. Chem. Front., 2016, 3, 1472 DOI: 10.1039/C6QO00358C

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