Issue 12, 2016

Silver(i)-promoted C5–H phosphonation of 8-aminoquinoline amides with H-phosphonates

Abstract

A simple and efficient protocol for silver(I)-promoted phosphonation of 8-aminoquinoline amides with dialkyl H-phosphonates has been developed, affording the desired products in moderate yields. This method features C5–H regioselectivity of 8-aminoquinoline amides, a broad substrate scope and general functional group compatibility.

Graphical abstract: Silver(i)-promoted C5–H phosphonation of 8-aminoquinoline amides with H-phosphonates

Supplementary files

Article information

Article type
Research Article
Submitted
21 Jul 2016
Accepted
15 Sep 2016
First published
19 Sep 2016

Org. Chem. Front., 2016,3, 1646-1650

Silver(I)-promoted C5–H phosphonation of 8-aminoquinoline amides with H-phosphonates

M. Sun, S. Sun, H. Qiao, F. Yang, Y. Zhu, J. Kang, Y. Wu and Y. Wu, Org. Chem. Front., 2016, 3, 1646 DOI: 10.1039/C6QO00379F

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