Issue 11, 2016

Sulfonyl radical-enabled 6-endo-trig cyclization for regiospecific synthesis of unsymmetrical diaryl sulfones

Abstract

A new sulfonyl radical-triggered 6-endo-trig cyclization of unactivated 1,5-enynes under catalytic oxidation conditions for flexible synthesis of unprecedented unsymmetrical diaryl sulfones was established. This transformation could also proceed smoothly using 2-arylalkynyl-1,1′-biphenyls, delivering new sulfonylated phenanthrenes. The synthetic utility of these transformations results in subsequent C–S and C–C bond-forming reactions to effectively build up functional sulfones with potential significance.

Graphical abstract: Sulfonyl radical-enabled 6-endo-trig cyclization for regiospecific synthesis of unsymmetrical diaryl sulfones

Supplementary files

Article information

Article type
Research Article
Submitted
01 Aug 2016
Accepted
22 Aug 2016
First published
23 Aug 2016

Org. Chem. Front., 2016,3, 1452-1456

Sulfonyl radical-enabled 6-endo-trig cyclization for regiospecific synthesis of unsymmetrical diaryl sulfones

R. Fu, W. Hao, Y. Wu, N. Wang, S. Tu, G. Li and B. Jiang, Org. Chem. Front., 2016, 3, 1452 DOI: 10.1039/C6QO00422A

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