Issue 12, 2016

Synthesis of spiro[indane-1,3-dione-1-pyrrolines] via copper-catalyzed heteroannulation of ketoxime acetates with 2-arylideneindane-1,3-diones

Abstract

A cuprous cyanide-catalyzed heteroannulation reaction of 2-arylideneindane-1,3-dione with ketoxime acetates has been developed for the synthesis of novel spiro[indane-1,3-dione-1-pyrrolines] through the cleavage of N–O and C–H bonds and formation of C–C and C–N bonds. The synthetic strategy shows broad substrate scope and furnishes spiro[indane-1,3-dione-1-pyrrolines] in high yields.

Graphical abstract: Synthesis of spiro[indane-1,3-dione-1-pyrrolines] via copper-catalyzed heteroannulation of ketoxime acetates with 2-arylideneindane-1,3-diones

Supplementary files

Article information

Article type
Research Article
Submitted
12 Aug 2016
Accepted
26 Sep 2016
First published
27 Sep 2016

Org. Chem. Front., 2016,3, 1614-1618

Synthesis of spiro[indane-1,3-dione-1-pyrrolines] via copper-catalyzed heteroannulation of ketoxime acetates with 2-arylideneindane-1,3-diones

J. Duan, Y. Cheng, R. Li and P. Li, Org. Chem. Front., 2016, 3, 1614 DOI: 10.1039/C6QO00454G

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