Supramolecular nanofibers of self-assembling peptides and DDP to inhibit cancer cell growth

Xiaoli Zhang; Can Li; Youzhi Wang; Caiwen Ou; Shenglu Ji; Minsheng Chen; Zhimou Yang

doi:10.1039/C6RA08357A

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Supramolecular nanofibers of self-assembling peptides and DDP to inhibit cancer cell growth†

Xiaoli Zhang,^a Can Li,^a Youzhi Wang,

^a Caiwen Ou,^b Shenglu Ji,^a Minsheng Chen*^b and Zhimou Yang*^a

Author affiliations

* Corresponding authors

^a State Key Laboratory of Medicinal Chemical Biology, Key Laboratory of Bioactive Materials, Ministry of Education and College of Life Sciences, Nankai University and Collaborative Innovation Center of Chemical Science and Engineering, Tianjin 300071, P. R. China
E-mail: yangzm@nankai.edu.cn

^b Department of Cardiology, Zhujiang Hospital of Southern Medical University, Guangzhou 510280, P. R. China
E-mail: gzminsheng@vip.163.com

Abstract

We report in this paper a molecular hydrogel formed by adding cis-dichlorodiamineplatinum(II) (DDP) to a self-assembling taxol-peptide amphiphile. Our study provides a novel self-assembling nanomedicine and hydrogel to deliver two anti-cancer drugs simultaneously.

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Article information

DOI: https://doi.org/10.1039/C6RA08357A
Article type: Communication
Submitted: 01 Apr 2016
Accepted: 07 Jun 2016
First published: 08 Jun 2016

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RSC Adv., 2016,6, 56903-56906

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Supramolecular nanofibers of self-assembling peptides and DDP to inhibit cancer cell growth

X. Zhang, C. Li, Y. Wang, C. Ou, S. Ji, M. Chen and Z. Yang, RSC Adv., 2016, 6, 56903 DOI: 10.1039/C6RA08357A

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Supramolecular nanofibers of self-assembling peptides and DDP to inhibit cancer cell growth†

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