Issue 1, 2017
From the journal:

Chemical Science

Zirconocene catalyzed diastereoselective carbometalation of cyclobutenes†

Sudipta Raha Roy,a   Hendrik Eijsberg,a   Jeffrey Bruffaertsa  and  Ilan Marek*a  

* Corresponding authors

a The Mallat Family Laboratory of Organic Chemistry, Schulich Faculty of Chemistry and Lise Meitner-Minerva Center for Computational Quantum Chemistry, Technion-Israel Institute of Technology, Technion City, Haifa 32000, Israel
E-mail: chilanm@tx.technion.ac.il
Fax: +972-4-829-37-09
Tel: +972-4-829-37-09

Abstract

The regio- and diastereoselective zirconocene-catalyzed carbomagnesiation of cyclobutenes is herein reported to afford configurationally stable cyclobutylmagnesium species that could subsequently react with a large variety of electrophiles to give polysubstituted cyclobutane species as a single diastereoisomer.

Graphical abstract: Zirconocene catalyzed diastereoselective carbometalation of cyclobutenes

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Article information

DOI
https://doi.org/10.1039/C6SC02617F
Article type
Edge Article
Submitted
15 Jun 2016
Accepted
04 Aug 2016
First published
30 Aug 2016
This article is Open Access

All publication charges for this article have been paid for by the Royal Society of Chemistry
Creative Commons BY license

Chem. Sci., 2017,8, 334-339

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Zirconocene catalyzed diastereoselective carbometalation of cyclobutenes

S. R. Roy, H. Eijsberg, J. Bruffaerts and I. Marek, Chem. Sci., 2017, 8, 334 DOI: 10.1039/C6SC02617F

This article is licensed under a Creative Commons Attribution 3.0 Unported Licence. You can use material from this article in other publications without requesting further permissions from the RSC, provided that the correct acknowledgement is given.

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