Issue 4, 2017

Zwitterionic near infrared fluorescent agents for noninvasive real-time transcutaneous assessment of kidney function

Abstract

We developed novel zwitterionic near infrared (NIR) fluorescent agents (ABZWCY-HPβCD and AAZWCY-HPβCD), which exhibit favorable hydrophilicity, low plasma protein binding, high stability and non-toxicity. These attractive characteristics ensure that they are excreted rapidly, without any skin accumulation or metabolism in vivo. More importantly, zwitterionic HPβCD based agents can be efficiently filtrated by the glomerulus and completely excreted through the kidneys into urine without reabsorption or secretion in the kidney proximal tubule. Relying on these novel zwitterionic NIR agents and a transcutaneous device, we demonstrate a rapid, robust and biocompatible approach for assessing kidney function in rat models of both healthy rats and those with kidney disease, without the need for time-consuming blood/urine sample preparation. Our work provides a promising tool for in vivo real-time non-invasive kidney function assessment in preclinical applications.

Graphical abstract: Zwitterionic near infrared fluorescent agents for noninvasive real-time transcutaneous assessment of kidney function

Supplementary files

Article information

Article type
Edge Article
Submitted
16 Nov 2016
Accepted
08 Jan 2017
First published
11 Jan 2017
This article is Open Access

All publication charges for this article have been paid for by the Royal Society of Chemistry
Creative Commons BY license

Chem. Sci., 2017,8, 2652-2660

Zwitterionic near infrared fluorescent agents for noninvasive real-time transcutaneous assessment of kidney function

J. Huang, S. Weinfurter, C. Daniele, R. Perciaccante, R. Federica, L. Della Ciana, J. Pill and N. Gretz, Chem. Sci., 2017, 8, 2652 DOI: 10.1039/C6SC05059J

This article is licensed under a Creative Commons Attribution 3.0 Unported Licence. You can use material from this article in other publications without requesting further permissions from the RSC, provided that the correct acknowledgement is given.

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