Issue 1, 2018

Expanding the structural analysis capabilities on an Orbitrap-based mass spectrometer for large macromolecular complexes

Abstract

Native mass spectrometry can provide insight into the structure of macromolecular biological systems. As analytes under investigation get larger and more complex, instrument capabilities need to be advanced. Herein, modifications to an Orbitrap Q Exactive Plus mass spectrometer that increase signal intensity, mass resolution, and maximum m/z measurable are described.

Graphical abstract: Expanding the structural analysis capabilities on an Orbitrap-based mass spectrometer for large macromolecular complexes

Supplementary files

Article information

Article type
Communication
Submitted
02 Oct 2017
Accepted
08 Nov 2017
First published
08 Nov 2017

Analyst, 2018,143, 100-105

Expanding the structural analysis capabilities on an Orbitrap-based mass spectrometer for large macromolecular complexes

K. L. Fort, M. van de Waterbeemd, D. Boll, M. Reinhardt-Szyba, M. E. Belov, E. Sasaki, R. Zschoche, D. Hilvert, A. A. Makarov and A. J. R. Heck, Analyst, 2018, 143, 100 DOI: 10.1039/C7AN01629H

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