Issue 1, 2018

Chemical amplification accelerates reactive oxygen species triggered polymeric degradation

Abstract

Chemical amplification is a known strategy for improving the sensitivity of stimuli-responsive polymers. However, the chemical amplification effect has never been fully examined. Many questions remain about its mechanism and efficacy, obstructing its further implementation. Here, we design and demonstrate a reactive oxygen species (ROS) responsive polymer (ROS-ARP) with a chemical amplification strategy to dismiss these concerns. The ROS-ARP is designed to change the hydrophilicity by ROS, revealing a carboxylic acid, which also catalyzes ketal hydrolysis along the polymer backbone. The chemical amplification strategy of ROS-ARP accelerated the polymer degradation up to 17 fold compared to a previously reported ROS-responsive polymer. To investigate the mechanism behind this increased acceleration, we compared the degradation kinetics in various environments. Additionally, other effects such as hydrophilicity changes were excluded. The accelerated degradation of ROS-ARP is evaluated as a potential drug delivery system, demonstrating on-demand cargo release from the formulated polymeric particles.

Graphical abstract: Chemical amplification accelerates reactive oxygen species triggered polymeric degradation

Supplementary files

Article information

Article type
Paper
Submitted
19 Aug 2017
Accepted
08 Nov 2017
First published
28 Nov 2017

Biomater. Sci., 2018,6, 107-114

Chemical amplification accelerates reactive oxygen species triggered polymeric degradation

S. Lee, A. Stubelius, J. Olejniczak, H. Jang, V. A. N. Huu and A. Almutairi, Biomater. Sci., 2018, 6, 107 DOI: 10.1039/C7BM00758B

To request permission to reproduce material from this article, please go to the Copyright Clearance Center request page.

If you are an author contributing to an RSC publication, you do not need to request permission provided correct acknowledgement is given.

If you are the author of this article, you do not need to request permission to reproduce figures and diagrams provided correct acknowledgement is given. If you want to reproduce the whole article in a third-party publication (excluding your thesis/dissertation for which permission is not required) please go to the Copyright Clearance Center request page.

Read more about how to correctly acknowledge RSC content.

Social activity

Spotlight

Advertisements