Issue 25, 2017

Structural insights into the EthR–DNA interaction using native mass spectrometry

Abstract

EthR is a transcriptional repressor that increases Mycobacterium tuberculosis resistance to ethionamide. In this study, the EthR–DNA interaction has been investigated by native electrospray-ionization mass spectrometry for the first time. The results show that up to six subunits of EthR are able to bind to its operator.

Graphical abstract: Structural insights into the EthR–DNA interaction using native mass spectrometry

Supplementary files

Article information

Article type
Communication
Submitted
30 Jan 2017
Accepted
07 Mar 2017
First published
07 Mar 2017
This article is Open Access
Creative Commons BY license

Chem. Commun., 2017,53, 3527-3530

Structural insights into the EthR–DNA interaction using native mass spectrometry

D. Shiu-Hin Chan, W. Seetoh, B. N. McConnell, D. Matak-Vinković, S. E. Thomas, V. Mendes, M. Blaszczyk, A. G. Coyne, T. L. Blundell and C. Abell, Chem. Commun., 2017, 53, 3527 DOI: 10.1039/C7CC00804J

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