Issue 50, 2017
From the journal:

Chemical Communications

Intracellular delivery of a catalytic organometallic complex†

Eugenio Indrigo,‡a   Jessica Clavadetscher,‡a   Sunay V. Chankeshwara, ORCID logo a   Alicia Megia-Fernandez,a   Annamaria Lilienkampfa  and  Mark Bradley ORCID logo *a  

* Corresponding authors

a EaStCHEM, School of Chemistry, University of Edinburgh, David Brewster Road, EH9 3FJ Edinburgh, UK
E-mail: Mark.Bradley@ed.ac.uk

Abstract

A homogeneous carbene-based palladium catalyst was conjugated to a cell-penetrating peptide, allowing intracellular delivery of catalytically active Pd complexes that demonstrated bioorthogonal activation of a profluorophore within prostate cancer cells.

Graphical abstract: Intracellular delivery of a catalytic organometallic complex

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Article information

DOI
https://doi.org/10.1039/C7CC02988H
Article type
Communication
Submitted
18 Apr 2017
Accepted
31 May 2017
First published
06 Jun 2017
This article is Open Access
Creative Commons BY license

Chem. Commun., 2017,53, 6712-6715

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Intracellular delivery of a catalytic organometallic complex

E. Indrigo, J. Clavadetscher, S. V. Chankeshwara, A. Megia-Fernandez, A. Lilienkampf and M. Bradley, Chem. Commun., 2017, 53, 6712 DOI: 10.1039/C7CC02988H

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