Issue 61, 2017

Evaluation of DFO-HOPO as an octadentate chelator for zirconium-89

Abstract

The future of 89Zr-based immuno-PET is reliant upon the development of new chelators with improved stability compared to the currently used deferoxamine (DFO). Herein, we report the evaluation of the octadentate molecule DFO-HOPO (3) as a suitable chelator for 89Zr and a more stable alternative to DFO. The molecule showed good potential for the future development of a DFO-HOPO-based bifunctional chelator (BFC) for the radiolabelling of biomolecules with 89Zr. This work broadens the selection of available chelators for 89Zr in search of improved successors to DFO for clinical 89Zr-immuno-PET.

Graphical abstract: Evaluation of DFO-HOPO as an octadentate chelator for zirconium-89

Supplementary files

Article information

Article type
Communication
Submitted
08 May 2017
Accepted
07 Jul 2017
First published
12 Jul 2017
This article is Open Access
Creative Commons BY license

Chem. Commun., 2017,53, 8529-8532

Evaluation of DFO-HOPO as an octadentate chelator for zirconium-89

L. Allott, C. Da Pieve, J. Meyers, T. Spinks, D. M. Ciobota, G. Kramer-Marek and G. Smith, Chem. Commun., 2017, 53, 8529 DOI: 10.1039/C7CC03572A

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