Issue 1, 2018

Near infrared imaging of Mer tyrosine kinase (MERTK) using MERi-SiR reveals tumor associated macrophage uptake in metastatic disease

Abstract

The receptor tyrosine kinase Mer (MERTK) is a promising drug target in cancer, where it can influence the metastasis-promoting signaling of both tumor cells and immune cells alike; however, no small molecule probes currently exist to selectively image Mer. In this work, we design and synthesize a selective near-infrared fluorescent molecular probe of Mer (MERi-SiR). Confocal microscopy of metastases in mice reveals predominant probe accumulation in Mer-expressing tumor-associated macrophages.

Graphical abstract: Near infrared imaging of Mer tyrosine kinase (MERTK) using MERi-SiR reveals tumor associated macrophage uptake in metastatic disease

Supplementary files

Article information

Article type
Communication
Submitted
28 Sep 2017
Accepted
23 Nov 2017
First published
23 Nov 2017

Chem. Commun., 2018,54, 42-45

Near infrared imaging of Mer tyrosine kinase (MERTK) using MERi-SiR reveals tumor associated macrophage uptake in metastatic disease

M. A. Miller, E. Kim, M. F. Cuccarese, A. L. Plotkin, M. Prytyskach, R. H. Kohler, M. J. Pittet and R. Weissleder, Chem. Commun., 2018, 54, 42 DOI: 10.1039/C7CC07581B

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