Issue 93, 2017

Towards broad spectrum activity-based glycosidase probes: synthesis and evaluation of deoxygenated cyclophellitol aziridines

Abstract

Activity-based protein profiling has emerged as a powerful tool for visualizing glycosidases in complex biological samples. Several configurational cyclophellitol isomers have been shown to display high selectivity as probes for glycosidases processing substrates featuring the same configuration. Here, a set of deoxygenated cyclophellitols are presented which enable inter-class profiling of β-glucosidases and β-galactosidases.

Graphical abstract: Towards broad spectrum activity-based glycosidase probes: synthesis and evaluation of deoxygenated cyclophellitol aziridines

Supplementary files

Article information

Article type
Communication
Submitted
05 Oct 2017
Accepted
03 Nov 2017
First published
03 Nov 2017
This article is Open Access
Creative Commons BY license

Chem. Commun., 2017,53, 12528-12531

Towards broad spectrum activity-based glycosidase probes: synthesis and evaluation of deoxygenated cyclophellitol aziridines

S. P. Schröder, J. W. van de Sande, W. W. Kallemeijn, C. Kuo, M. Artola, E. J. van Rooden, J. Jiang, T. J. M. Beenakker, B. I. Florea, W. A. Offen, G. J. Davies, A. J. Minnaard, J. M. F. G. Aerts, J. D. C. Codée, G. A. van der Marel and H. S. Overkleeft, Chem. Commun., 2017, 53, 12528 DOI: 10.1039/C7CC07730K

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