Issue 95, 2017

Long-wavelength fluorescent boronate probes for the detection and intracellular imaging of peroxynitrite

Abstract

Two boronate fluorescent probes have been developed for the detection of peroxynitrite (TCFB1 and TCFB2). TCFB1 was shown to have a low sensitvity towards peroxynitrite and have a poor solubility in aqueous solution whereas TCFB2 demonstrated high sensitivity towards peroxynitrite and mitochondria localisation with the ability to detect exogenous and endogenous peroxynitrite in live cells (Hep-G2, RAW 264.7, HeLa and A459).

Graphical abstract: Long-wavelength fluorescent boronate probes for the detection and intracellular imaging of peroxynitrite

Supplementary files

Article information

Article type
Communication
Submitted
10 Oct 2017
Accepted
03 Nov 2017
First published
08 Nov 2017
This article is Open Access
Creative Commons BY license

Chem. Commun., 2017,53, 12822-12825

Long-wavelength fluorescent boronate probes for the detection and intracellular imaging of peroxynitrite

A. C. Sedgwick, H. Han, J. E. Gardiner, S. D. Bull, X. He and T. D. James, Chem. Commun., 2017, 53, 12822 DOI: 10.1039/C7CC07845E

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