Issue 92, 2017

Dual-target cancer theranostic for glutathione S-transferase and hypoxia-inducible factor-1α inhibition

Abstract

We developed a dual-target theranostic F671, which could exhibit synergetic anticancer effects for inhibiting the activities of glutathione S-transferase and the accumulation of hypoxia inducible factor-1α. F671 undergoes self-immolative cleavage when exposed to GSTP1-1 in live cancer cells, facilitating the visualization of molecule release and distribution, as well as confirming the autophagy-induced apoptosis.

Graphical abstract: Dual-target cancer theranostic for glutathione S-transferase and hypoxia-inducible factor-1α inhibition

Supplementary files

Article information

Article type
Communication
Submitted
23 Oct 2017
Accepted
30 Oct 2017
First published
30 Oct 2017

Chem. Commun., 2017,53, 12406-12409

Dual-target cancer theranostic for glutathione S-transferase and hypoxia-inducible factor-1α inhibition

Z. Li, J. Ding, C. Chen, J. Chang, B. Huang, Z. Geng and Z. Wang, Chem. Commun., 2017, 53, 12406 DOI: 10.1039/C7CC08162F

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