Issue 12, 2018

Non-natural amino acid peptide microarrays to discover Ebola virus glycoprotein ligands

Abstract

We demonstrate a platform to screen a virus pseudotyped with Ebola virus glycoprotein (GP) against a library of peptides that contain non-natural amino acids to develop GP affinity ligands. This system could be used for rapid development of peptide-based antivirals for other emerging or neglected tropical infectious diseases.

Graphical abstract: Non-natural amino acid peptide microarrays to discover Ebola virus glycoprotein ligands

Supplementary files

Article information

Article type
Communication
Submitted
26 Oct 2017
Accepted
20 Dec 2017
First published
03 Jan 2018

Chem. Commun., 2018,54, 1417-1420

Non-natural amino acid peptide microarrays to discover Ebola virus glycoprotein ligands

J. A. Rabinowitz, J. C. Lainson, S. A. Johnston and C. W. Diehnelt, Chem. Commun., 2018, 54, 1417 DOI: 10.1039/C7CC08242H

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