Issue 28, 2017
From the journal:

Dalton Transactions

Oxaliplatin reacts with DMSO only in the presence of water†

Hristo P. Varbanov, ORCID logo *ab   Daniel Ortiz,a   Doris Höfer,b   Laure Menin,a   Mathea S. Galanski,b   Bernhard K. Kepplerb  and  Paul J. Dyson*a  

* Corresponding authors

a Institut des Sciences et Ingénierie Chimiques, Ecole Polytechnique Fédérale de Lausanne (EPFL), Lausanne, Switzerland
E-mail: paul.dyson@epfl.ch

b Institute of Inorganic Chemistry, University of Vienna, Waehringer Strasse 42, A-1090 Vienna, Austria
E-mail: hristo.varbanov@univie.ac.at

Abstract

Herein we show that oxaliplatin reacts rapidly with DMSO in aqueous solutions, despite being stable in pure DMSO and pure water. Furthermore, the reactivity of the clinically applied Pt(II) drugs in water/DMSO and PBS/DMSO mixtures, and the nature of the species formed were investigated by MS, NMR and RP-HPLC techniques.

Graphical abstract: Oxaliplatin reacts with DMSO only in the presence of water

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Article information

DOI
https://doi.org/10.1039/C7DT01628J
Article type
Communication
Submitted
04 May 2017
Accepted
05 Jun 2017
First published
27 Jun 2017
This article is Open Access
Creative Commons BY license

Dalton Trans., 2017,46, 8929-8932

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Oxaliplatin reacts with DMSO only in the presence of water

H. P. Varbanov, D. Ortiz, D. Höfer, L. Menin, M. S. Galanski, B. K. Keppler and P. J. Dyson, Dalton Trans., 2017, 46, 8929 DOI: 10.1039/C7DT01628J

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