Issue 1, 2018

Synthesis of cubic spherosilicates for self-assembled organic–inorganic biohybrids based on functionalized methacrylates

Abstract

The aim of this work is to develop an efficient synthetic approach to hexahedral cage-like organic–inorganic siloxane core biohybrids containing side chains fully functionalized by methacrylate groups derived from monomers such as 2-hydroxyethyl methacrylate (HEMA) or ethylene glycol dimethacrylate (EGDMA). The resulting hybrids were characterized using spectroscopic methods (FTIR, 1H, 13C, 29Si NMR), thermogravimetric and DSC analyses, and high resolution mass spectrometry (HR-MS). The obtained compounds, after polycondensation/polymerization reactions, were utilized in constructing 3D macroporous scaffolds which were examined using a scanning electron microscope (SEM). Covalent networks created by fully functionalized cubic spherosilicates can mimic certain biomaterials and constitute sophisticated, highly organized building blocks of complex systems.

Graphical abstract: Synthesis of cubic spherosilicates for self-assembled organic–inorganic biohybrids based on functionalized methacrylates

Supplementary files

Article information

Article type
Paper
Submitted
12 Jul 2017
Accepted
23 Nov 2017
First published
23 Nov 2017
This article is Open Access
Creative Commons BY license

New J. Chem., 2018,42, 39-47

Synthesis of cubic spherosilicates for self-assembled organic–inorganic biohybrids based on functionalized methacrylates

Ł. John, M. Janeta and S. Szafert, New J. Chem., 2018, 42, 39 DOI: 10.1039/C7NJ02533E

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