Issue 24, 2017
From the journal:

New Journal of Chemistry

Dialkylgallium alkoxides – a tool for facile and stereoselective synthesis of PLA–drug conjugates†

M. Cybularczyk-Cecotka,ab   R. Zaremba,ab   A. Hurko,ac   A. Plichta,c   M. Drankac  and  P. Horeglad ORCID logo *a  

* Corresponding authors

a Centre of New Technologies, University of Warsaw, Banacha 2c, 02-097 Warsaw, Poland
E-mail: phoreglad@uw.edu.pl

b Faculty of Chemistry, University of Warsaw, Pasteura 1, 02-093 Warsaw, Poland

c Faculty of Chemistry, Warsaw University of Technology, Noakowskiego 3, Warsaw, Poland

Abstract

Herein, a method for the synthesis of PLA-(β-blocker) conjugates with a tunable stereostructure of the PLA fragment is demonstrated using stereoselective [R2Ga(μ-β-blocker)]2 catalysts and [R2Ga(μ-OR)]2/H-(β-blocker) catalytic systems for the ring-opening polymerisation (ROP) and immortal ring-opening polymerisation (iROP) of racemic lactide (rac-LA), respectively.

Graphical abstract: Dialkylgallium alkoxides – a tool for facile and stereoselective synthesis of PLA–drug conjugates

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Article information

DOI
https://doi.org/10.1039/C7NJ03089D
Article type
Letter
Submitted
18 Aug 2017
Accepted
09 Nov 2017
First published
10 Nov 2017
This article is Open Access
Creative Commons BY license

New J. Chem., 2017,41, 14851-14854

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Dialkylgallium alkoxides – a tool for facile and stereoselective synthesis of PLA–drug conjugates

M. Cybularczyk-Cecotka, R. Zaremba, A. Hurko, A. Plichta, M. Dranka and P. Horeglad, New J. Chem., 2017, 41, 14851 DOI: 10.1039/C7NJ03089D

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