Issue 31, 2017

Phase and morphological control of MoO3−x nanostructures for efficient cancer theragnosis therapy

Abstract

Nanostructures of metal oxide semiconductors play significant roles in a variety of areas, such as biotherapy, pollutant treatment and energy storage and conversion. The molybdenum oxide (MoO3−x) nanostructures have shown promising applications especially when used as photothermal treatment agents due to their relatively low cost, facile synthesis and low toxicity. However, the design and synthesis of efficient MoO3−x nanomaterials with tunable phases and morphologies for theragnosis of tumors remains a challenge. In this work, hydrophilic MoO3−x with controlled structures and phases was synthesized by a simple one-step hydrothermal process. The as-obtained MoO2 nanoclusters showed a desirable size of ∼40 nm in diameter exhibiting unique properties as a theragnosis nanoplatform: (1) strong near-infrared absorption, which is due to oxygen vacancies of the nanoclusters, as proved by photoluminescence spectroscopy and X-ray photoelectron spectroscopy; (2) excellent photothermal performance with a photothermal conversion efficiency of up to 62.1%; and (3) the image response of X-ray computed tomography (CT) and infrared thermal imaging for simultaneous diagnosis of tumors. This study provided the facile synthetic strategy for controllable metal oxide semiconductors and promoted the development of metal oxides for theragnosis therapy of cancers.

Graphical abstract: Phase and morphological control of MoO3−x nanostructures for efficient cancer theragnosis therapy

Supplementary files

Article information

Article type
Communication
Submitted
15 May 2017
Accepted
23 Jul 2017
First published
25 Jul 2017
This article is Open Access
Creative Commons BY license

Nanoscale, 2017,9, 11012-11016

Phase and morphological control of MoO3−x nanostructures for efficient cancer theragnosis therapy

B. Li, X. Wang, X. Wu, G. He, R. Xu, X. Lu, F. R. Wang and I. P. Parkin, Nanoscale, 2017, 9, 11012 DOI: 10.1039/C7NR03469E

This article is licensed under a Creative Commons Attribution 3.0 Unported Licence. You can use material from this article in other publications without requesting further permissions from the RSC, provided that the correct acknowledgement is given.

Read more about how to correctly acknowledge RSC content.

Social activity

Spotlight

Advertisements