Issue 1, 2018

Scandium-catalyzed C(sp3)–H alkylation of N,N-dimethyl anilines with alkenes

Abstract

A scandium complex based on a new type of tridentate ligand enabled an atom- and step-economical C(sp3)–H addition of N,N-dimethyl anilines to a variety of unactivated alkenes affording branched products for the first time. A cationic o-dimethylaminophenyl scandium species was isolated and confirmed as the catalytic intermediate in this transformation.

Graphical abstract: Scandium-catalyzed C(sp3)–H alkylation of N,N-dimethyl anilines with alkenes

Supplementary files

Article information

Article type
Research Article
Submitted
14 Aug 2017
Accepted
19 Sep 2017
First published
20 Sep 2017

Org. Chem. Front., 2018,5, 59-63

Scandium-catalyzed C(sp3)–H alkylation of N,N-dimethyl anilines with alkenes

H. Gao, J. Su, P. Xu and X. Xu, Org. Chem. Front., 2018, 5, 59 DOI: 10.1039/C7QO00718C

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