Issue 58, 2017, Issue in Progress

Anti-microbial activity of chrysomycin A produced by Streptomyces sp. against Mycobacterium tuberculosis

Abstract

Limited efficacy of the BCG (Bacillus Calmette–Guérin) vaccine against adult tuberculosis and the emergence of resistance to existing anti-tuberculosis drugs compel discovery of novel antibiotics against Mycobacterium tuberculosis. Actinomycetes are still an attractive platform for the discovery of new antimicrobials, especially from untapped natural hotspots, despite the belief that they are an exhausted resource after repeated re-discoveries. Herein we report the isolation and identification of chrysomycin A from an actinomycete isolated from a coastal area in Kerala. We show for the first time that it has antimycobacterial activity. It was found to be bactericidal to planktonic and intracellular M. tuberculosis with an MIC of 3.125 μg mL−1; it is non-hemolytic and has negligible cytotoxicity. The actinomycete that produces chrysomycin A was found to be a Streptomyces sp. through 16S rRNA gene sequencing.

Graphical abstract: Anti-microbial activity of chrysomycin A produced by Streptomyces sp. against Mycobacterium tuberculosis

Supplementary files

Article information

Article type
Paper
Submitted
17 May 2017
Accepted
04 Jul 2017
First published
21 Jul 2017
This article is Open Access
Creative Commons BY-NC license

RSC Adv., 2017,7, 36335-36339

Anti-microbial activity of chrysomycin A produced by Streptomyces sp. against Mycobacterium tuberculosis

B. Muralikrishnan, V. M. Dan, J. S. Vinodh, V. Jamsheena, R. Ramachandran, S. Thomas, S. G. Dastager, K. S. Kumar, R. S. Lankalapalli and R. A. Kumar, RSC Adv., 2017, 7, 36335 DOI: 10.1039/C7RA05576E

This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence. You can use material from this article in other publications, without requesting further permission from the RSC, provided that the correct acknowledgement is given and it is not used for commercial purposes.

To request permission to reproduce material from this article in a commercial publication, please go to the Copyright Clearance Center request page.

If you are an author contributing to an RSC publication, you do not need to request permission provided correct acknowledgement is given.

If you are the author of this article, you do not need to request permission to reproduce figures and diagrams provided correct acknowledgement is given. If you want to reproduce the whole article in a third-party commercial publication (excluding your thesis/dissertation for which permission is not required) please go to the Copyright Clearance Center request page.

Read more about how to correctly acknowledge RSC content.

Social activity

Spotlight

Advertisements