Issue 12, 2017

Copper-catalyzed aminoalkynylation of alkenes with hypervalent iodine reagents

Abstract

A copper-catalyzed aminoalkynylation of alkenes is achieved with ethynylbenziodoxolone (EBX) reagents under mild conditions with only 1 mol% copper catalyst. This transformation allows for rapid construction of diverse important azahetereocycles and installation of valuable alkyne groups in one step. The developed method features remarkable substrate scope for both terminal and internal alkenes as well as different alkynyl groups, presenting great potential for broad applications in synthesis, bioconjugation, and molecular imaging.

Graphical abstract: Copper-catalyzed aminoalkynylation of alkenes with hypervalent iodine reagents

Supplementary files

Article information

Article type
Edge Article
Submitted
05 Aug 2017
Accepted
15 Oct 2017
First published
16 Oct 2017
This article is Open Access

All publication charges for this article have been paid for by the Royal Society of Chemistry
Creative Commons BY license

Chem. Sci., 2017,8, 8265-8270

Copper-catalyzed aminoalkynylation of alkenes with hypervalent iodine reagents

K. Shen and Q. Wang, Chem. Sci., 2017, 8, 8265 DOI: 10.1039/C7SC03420B

This article is licensed under a Creative Commons Attribution 3.0 Unported Licence. You can use material from this article in other publications without requesting further permissions from the RSC, provided that the correct acknowledgement is given.

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