Issue 5, 2018

Site-selective 18F fluorination of unactivated C–H bonds mediated by a manganese porphyrin

Abstract

The first direct C–H 18F fluorination reaction of unactivated aliphatic sites using no-carrier-added [18F]fluoride is reported. Under the influence of a manganese porphyrin/iodosylbenzene system, a variety of unactivated aliphatic C–H bonds can be selectively converted to C–18F bonds. The mild conditions, broad substrate scope and generally inaccessible regiochemistry make this radio-fluorination a powerful alternate to established nucleophilic substitution for the preparation of 18F labeled radio tracers.

Graphical abstract: Site-selective 18F fluorination of unactivated C–H bonds mediated by a manganese porphyrin

Supplementary files

Article information

Article type
Edge Article
Submitted
19 Oct 2017
Accepted
02 Dec 2017
First published
05 Dec 2017
This article is Open Access

All publication charges for this article have been paid for by the Royal Society of Chemistry
Creative Commons BY-NC license

Chem. Sci., 2018,9, 1168-1172

Site-selective 18F fluorination of unactivated C–H bonds mediated by a manganese porphyrin

W. Liu, X. Huang, M. S. Placzek, S. W. Krska, P. McQuade, J. M. Hooker and J. T. Groves, Chem. Sci., 2018, 9, 1168 DOI: 10.1039/C7SC04545J

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