Highly sensitive and stable zwitterionic poly(sulfobetaine-3,4-ethylenedioxythiophene) (PSBEDOT) glucose biosensor

Haiyan Wu; Chen-Jung Lee; Huifeng Wang; Yang Hu; Megan Young; Yu Han; Fu-Jian Xu; Hongbo Cong; Gang Cheng

doi:10.1039/C7SC05104B

Highly sensitive and stable zwitterionic poly(sulfobetaine-3,4-ethylenedioxythiophene) (PSBEDOT) glucose biosensor†

Haiyan Wu,

^a Chen-Jung Lee,^a Huifeng Wang,^b Yang Hu,^b Megan Young,^b Yu Han,^c Fu-Jian Xu,

^d Hongbo Cong

*^a and Gang Cheng

*^b

Author affiliations

* Corresponding authors

^a Department of Chemical and Biomolecular Engineering, University of Akron, Akron, Ohio 44325, USA
E-mail: hcong@uakron.edu
Web: http://www.uakron.edu/engineering/about-us/people-directory/bio-detail.dot?u=hcong

^b Department of Chemical Engineering, University of Illinois at Chicago, Chicago, Illinois 60607, USA
E-mail: gancheng@uic.edu
Web: https://che.uic.edu/k-teacher/gang-cheng-ph-d/

^c Department of Mechanical Engineering, University of Akron, Akron, Ohio 44325, USA

^d Key Laboratory of Carbon Fiber and Functional Polymers (Ministry of Education), Beijing Laboratory of Biomedical Materials, Beijing University of Chemical Technology, Beijing 100029, China

Abstract

A zwitterionic poly(sulfobetaine-3,4-ethylenedioxythiophene) (PSBEDOT)-based glucose biosensor was fabricated via encapsulating glucose oxidase (GOx) in a one-step electropolymerization method. Integrating conductivity and hydrophilic properties, PSBEDOT provides a great framework for GOx immobilization and stabilization. The anti-fouling, high-sensitivity, and long-term stability properties of PSBEDOT–GOx make it a promising platform for long-term and continuous glucose monitoring.

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Article information

DOI: https://doi.org/10.1039/C7SC05104B
Article type: Edge Article
Submitted: 29 Nov 2017
Accepted: 24 Jan 2018
First published: 24 Jan 2018
This article is Open Access

All publication charges for this article have been paid for by the Royal Society of Chemistry

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Chem. Sci., 2018,9, 2540-2546

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Highly sensitive and stable zwitterionic poly(sulfobetaine-3,4-ethylenedioxythiophene) (PSBEDOT) glucose biosensor

H. Wu, C. Lee, H. Wang, Y. Hu, M. Young, Y. Han, F. Xu, H. Cong and G. Cheng, Chem. Sci., 2018, 9, 2540 DOI: 10.1039/C7SC05104B

This article is licensed under a Creative Commons Attribution 3.0 Unported Licence. You can use material from this article in other publications without requesting further permissions from the RSC, provided that the correct acknowledgement is given.

Chemical Science

Highly sensitive and stable zwitterionic poly(sulfobetaine-3,4-ethylenedioxythiophene) (PSBEDOT) glucose biosensor†

Abstract

Supplementary files

Article information

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Highly sensitive and stable zwitterionic poly(sulfobetaine-3,4-ethylenedioxythiophene) (PSBEDOT) glucose biosensor

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