Issue 35, 2018

Trisubstituted olefin synthesis via Ni-catalyzed hydroalkylation of internal alkynes with non-activated alkyl halides

Abstract

The stereoselective synthesis of tri-substituted alkenes is challenging. Herein, we report a Ni-catalyzed regio- and stereo-selective hydroalkylation of internal alkynes with non-activated alkyl halides. This method does not use any sensitive organometallic reagents and shows good functional group compatibility, which enables the efficient synthesis of many tri-substituted olefins from readily available coupling partners. It also provides a straightforward method for the modification of bioactive organic molecules.

Graphical abstract: Trisubstituted olefin synthesis via Ni-catalyzed hydroalkylation of internal alkynes with non-activated alkyl halides

Supplementary files

Article information

Article type
Communication
Submitted
26 Feb 2018
Accepted
27 Mar 2018
First published
28 Mar 2018

Chem. Commun., 2018,54, 4417-4420

Trisubstituted olefin synthesis via Ni-catalyzed hydroalkylation of internal alkynes with non-activated alkyl halides

X. Lu, M. Hong, H. Zhou, Y. Wang, J. Wang and X. Ge, Chem. Commun., 2018, 54, 4417 DOI: 10.1039/C8CC01577E

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