Issue 1, 2019
From the journal:

Chemical Communications

A new class of supramolecular ligands stabilizes 14-3-3 protein–protein interactions by up to two orders of magnitude†

A. Gigante, ORCID logo a   J.-N. Grad, ORCID logo b   J. Briels,ac   M. Bartel,ac   D. Hoffmann, ORCID logo *b   C. Ottmann ORCID logo *ac  and  C. Schmuck ORCID logo *a  

* Corresponding authors

a Institute of Organic Chemistry, University of Duisburg Essen, Universitätstr. 7, Essen, Germany
E-mail: carsten.schmuck@uni-due.de, christian.ottmann@uni-due.de

b Bioinformatics and Computational Biophysics, University of Duisburg Essen, Universitätstr. 7, Essen, Germany
E-mail: daniel.hoffmann@uni-due.de

c Department of Biomedical Engineering and Institute for Complex Molecular Systems, Technical University Eindhoven, P.O. Box 513, 5600 MB Eindhoven, The Netherlands
E-mail: c.ottmann@tue.nl

Abstract

We report the first supramolecular stabilizers of the interaction between 14-3-3ζ and two of its effectors, Tau and C-Raf, which are involved in neurodegenerative diseases and proliferative signal transduction, respectively. These supramolecular ligands open up an opportunity to modulate functions of 14-3-3 with these effectors.

Graphical abstract: A new class of supramolecular ligands stabilizes 14-3-3 protein–protein interactions by up to two orders of magnitude

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Article information

DOI
https://doi.org/10.1039/C8CC07946C
Article type
Communication
Submitted
04 Oct 2018
Accepted
26 Nov 2018
First published
26 Nov 2018

Chem. Commun., 2019,55, 111-114

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A new class of supramolecular ligands stabilizes 14-3-3 protein–protein interactions by up to two orders of magnitude

A. Gigante, J.-N. Grad, J. Briels, M. Bartel, D. Hoffmann, C. Ottmann and C. Schmuck, Chem. Commun., 2019, 55, 111 DOI: 10.1039/C8CC07946C

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