Issue 13, 2019

NAG-targeting fluorescence based probe for precision diagnosis of kidney injury

Abstract

We report an enzyme-activated fluorescence based probe (NHPO) for the selective detection of N-acetyl-β-D-glucosaminidase (NAG) activity in a drug-induced kidney injury mice model and NAG level in crude human urine. We used NHPO to explore the biological functions of NAG and provide a reference for the prognosis and prediction of proximal renal tubular dysfunction associated with various kidney diseases.

Graphical abstract: NAG-targeting fluorescence based probe for precision diagnosis of kidney injury

Supplementary files

Article information

Article type
Communication
Submitted
31 Dec 2018
Accepted
14 Jan 2019
First published
14 Jan 2019
This article is Open Access
Creative Commons BY license

Chem. Commun., 2019,55, 1955-1958

NAG-targeting fluorescence based probe for precision diagnosis of kidney injury

F. Yan, X. Tian, Z. Luan, L. Feng, X. Ma and T. D. James, Chem. Commun., 2019, 55, 1955 DOI: 10.1039/C8CC10311A

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