Issue 27, 2018

Cocrystal formation by ionic liquid-assisted grinding: case study with cocrystals of caffeine

Abstract

Liquid assisted grinding using imidazolium-based ionic liquids (IL-AG) was found to be effective in isolation of cocrystals and cocrystal polymorphs. Isolation of specific polymorphs of caffeine–citric acid (CAFCA) and caffeine–glutaric acid (CAFGLU) cocrystals highlights the tunability of ILs in polymorphic control.

Graphical abstract: Cocrystal formation by ionic liquid-assisted grinding: case study with cocrystals of caffeine

Supplementary files

Article information

Article type
Communication
Submitted
23 May 2018
Accepted
12 Jun 2018
First published
20 Jun 2018
This article is Open Access
Creative Commons BY-NC license

CrystEngComm, 2018,20, 3817-3821

Cocrystal formation by ionic liquid-assisted grinding: case study with cocrystals of caffeine

A. Mukherjee, R. D. Rogers and A. S. Myerson, CrystEngComm, 2018, 20, 3817 DOI: 10.1039/C8CE00859K

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