Issue 36, 2018

Cu-Catalyzed/mediated synthesis of N-fluoroalkylanilines from arylboronic acids: fluorine effect on the reactivity of fluoroalkylamines

Abstract

An oxidative coupling reaction of fluoroalkylamines with arylboronic acids has been achieved for the first time. Fluorine has profound influence on the reactivity and fluoroalkylated amines have the following reactivity trend: difluoroethylamine > trifluoroethylamine > pentafluoropropylamine ≈ heptafluorobutylamine.

Graphical abstract: Cu-Catalyzed/mediated synthesis of N-fluoroalkylanilines from arylboronic acids: fluorine effect on the reactivity of fluoroalkylamines

Supplementary files

Article information

Article type
Communication
Submitted
05 Jul 2018
Accepted
03 Aug 2018
First published
03 Aug 2018

Org. Biomol. Chem., 2018,16, 6634-6637

Cu-Catalyzed/mediated synthesis of N-fluoroalkylanilines from arylboronic acids: fluorine effect on the reactivity of fluoroalkylamines

H. Wang, Y. Tu, D. Liu and X. Hu, Org. Biomol. Chem., 2018, 16, 6634 DOI: 10.1039/C8OB01581C

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