Issue 3, 2019

Cross-dehydrogenative alkynylation of sulfonamides and amides with terminal alkynes via Ir(iii) catalysis

Abstract

Primary sulfonamides are widely used structural skeletons in bioactive molecules, however their direct modification via C–H functionalization remains to be developed. Herein, direct cross-dehydrogenative C–H alkynylations of amides and primary sulfonamides with terminal alkynes is reported. This general process features predictable regioselectivity towards multiple functionalized arenes and the stereoselective generation of tetrasubstituted olefins, which might provide insight into the expedient delivery of related bioactive and material molecules.

Graphical abstract: Cross-dehydrogenative alkynylation of sulfonamides and amides with terminal alkynes via Ir(iii) catalysis

Supplementary files

Article information

Article type
Research Article
Submitted
15 Oct 2018
Accepted
31 Oct 2018
First published
01 Nov 2018

Org. Chem. Front., 2019,6, 284-289

Cross-dehydrogenative alkynylation of sulfonamides and amides with terminal alkynes via Ir(III) catalysis

G. Wu, W. Ouyang, Q. Chen, Y. Huo and X. Li, Org. Chem. Front., 2019, 6, 284 DOI: 10.1039/C8QO01105B

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