Issue 21, 2018

PtO2/PTSA system catalyzed regioselective hydration of internal arylalkynes bearing electron withdrawing groups

Abstract

A highly efficient PtO2/PTSA catalyst system for the hydration of a wide array of alkynes was developed. This method proved to be compatible with a large range of functional groups and the ketone products were obtained in high yields. The scope of this methodology was also extended to the synthesis of 3-aryl-isochromenones, -indoles and -benzofurans.

Graphical abstract: PtO2/PTSA system catalyzed regioselective hydration of internal arylalkynes bearing electron withdrawing groups

Supplementary files

Article information

Article type
Paper
Submitted
19 Jan 2018
Accepted
07 Mar 2018
First published
23 Mar 2018
This article is Open Access
Creative Commons BY-NC license

RSC Adv., 2018,8, 11536-11542

PtO2/PTSA system catalyzed regioselective hydration of internal arylalkynes bearing electron withdrawing groups

H. Lin, N. Ibrahim, O. Provot, M. Alami and A. Hamze, RSC Adv., 2018, 8, 11536 DOI: 10.1039/C8RA00564H

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