Issue 19, 2018

Peroxoniobium inhibits leukemia cell growth

Abstract

A new class of polyoxoniobate complex has been synthesized and characterized as a novel anticancer agent for photodynamic therapy. The complex inhibits the growth of chronic myelogenous leukemia cells with an IC50 value of 30 μM, in the dark. However, upon exposure to light (365 nm) there is a fivefold increase in the cytotoxic activity. Light radiation activate the complex with the formation of radical species capable of interacting with DNA according to our experimental and theoretical data.

Graphical abstract: Peroxoniobium inhibits leukemia cell growth

Supplementary files

Article information

Article type
Paper
Submitted
29 Jan 2018
Accepted
08 Mar 2018
First published
14 Mar 2018
This article is Open Access
Creative Commons BY-NC license

RSC Adv., 2018,8, 10310-10313

Peroxoniobium inhibits leukemia cell growth

E. C. Pereira-Maia, I. P. Souza, K. J. R. C. Nunes, A. A. Castro, T. C. Ramalho, F. Steffler, H. A. Duarte, A. Pacheli, P. Chagas and L. C. A. Oliveira, RSC Adv., 2018, 8, 10310 DOI: 10.1039/C8RA00898A

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