Issue 29, 2018, Issue in Progress

Copper-catalyzed aerobic decarboxylative coupling between cyclic α-amino acids and diverse C–H nucleophiles with low catalyst loading

Abstract

An aerobic decarboxylative cross-coupling of α-amino acids with diverse C–H nucleophiles has been realized using Cu2(OH)2CO3 (1 mol%) as the catalyst under air. This protocol enables highly efficient formation of various C(sp3)–C(sp3), C(sp3)–C(sp2) and C(sp3)–C(sp) bonds under simple conditions without the use of any ligand or extra oxidant, providing a practical approach to numerous nitrogen-containing compounds in good to excellent yields. The efficiency and practicability were also demonstrated by the gram-scale experiment and three-step synthesis of a Rad51 inhibitor.

Graphical abstract: Copper-catalyzed aerobic decarboxylative coupling between cyclic α-amino acids and diverse C–H nucleophiles with low catalyst loading

Supplementary files

Article information

Article type
Paper
Submitted
16 Mar 2018
Accepted
26 Apr 2018
First published
01 May 2018
This article is Open Access
Creative Commons BY-NC license

RSC Adv., 2018,8, 16202-16206

Copper-catalyzed aerobic decarboxylative coupling between cyclic α-amino acids and diverse C–H nucleophiles with low catalyst loading

J. Guo, Y. Xie, Q. Wu, W. Zeng, A. S. C. Chan, J. Weng and G. Lu, RSC Adv., 2018, 8, 16202 DOI: 10.1039/C8RA02340A

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