Issue 34, 2018, Issue in Progress

Synthesis of diversely substituted bis-pyrrolizidino/ thiopyrrolizidino oxindolo/acenaphthyleno curcuminoids via sequential azomethine ylide cycloaddition

Abstract

Curcumin has been transformed to several diversely substituted bis-pyrrolizidino/thiopyrrolizidino oxindolo/acenaphthyleno curcuminoids via a sequential azomethine ylide cycloaddition reaction using isatins/acenaphthoquinone and proline/thioproline as the reagents. The products were separated via extensive chromatography and characterized by 1D/2D NMR and HRMS analysis.

Graphical abstract: Synthesis of diversely substituted bis-pyrrolizidino/ thiopyrrolizidino oxindolo/acenaphthyleno curcuminoids via sequential azomethine ylide cycloaddition

Supplementary files

Article information

Article type
Paper
Submitted
29 Mar 2018
Accepted
16 May 2018
First published
23 May 2018
This article is Open Access
Creative Commons BY license

RSC Adv., 2018,8, 18938-18951

Synthesis of diversely substituted bis-pyrrolizidino/ thiopyrrolizidino oxindolo/acenaphthyleno curcuminoids via sequential azomethine ylide cycloaddition

M. Singh, A. Hazra, Y. P. Bharitkar, R. Kalia, A. Sahoo, S. Saha, V. Ravichandiran, S. Ghosh and N. B. Mondal, RSC Adv., 2018, 8, 18938 DOI: 10.1039/C8RA02725K

This article is licensed under a Creative Commons Attribution 3.0 Unported Licence. You can use material from this article in other publications without requesting further permissions from the RSC, provided that the correct acknowledgement is given.

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