N2-selective alkylation of NH-1,2,3-triazoles with vinyl ethers via gold catalysis

Guoli Luo; Chenyang Sun; Yan Li; Xiaoxiao Li; Zhigang Zhao

doi:10.1039/C8RA04790A

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N²-selective alkylation of NH-1,2,3-triazoles with vinyl ethers via gold catalysis†

Guoli Luo,^a Chenyang Sun,^a Yan Li,^a Xiaoxiao Li

*^a and Zhigang Zhao*^a

Author affiliations

* Corresponding authors

^a College of Chemistry and Environmental Protection Engineering, Southwest Minzu University, Chengdu 610041, P. R. China
E-mail: lixiaoxiao.2005@163.com, zzg63129@163.com

Abstract

A new method was developed to synthesize N²-alkyl-substituted 1,2,3-triazoles via gold catalyzed alkylation of vinyl ethers with mono- and unsubstituted NH-1,2,3-triazoles and benzotriazole. A hydrogen bond between the oxygen atom of the vinyl ethers, activated via the gold catalyst, and the NH-1,2,3-triazoles was supposed to be generated, which selectively gave the N²-alkylation products.

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Article information

DOI: https://doi.org/10.1039/C8RA04790A
Article type: Paper
Submitted: 05 Jun 2018
Accepted: 04 Jul 2018
First published: 02 Aug 2018
This article is Open Access

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RSC Adv., 2018,8, 27610-27615

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N²-selective alkylation of NH-1,2,3-triazoles with vinyl ethers via gold catalysis

G. Luo, C. Sun, Y. Li, X. Li and Z. Zhao, RSC Adv., 2018, 8, 27610 DOI: 10.1039/C8RA04790A

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